Products for Research Use Only
RegisterLogin

MT-228

CAT: 0804-HY-175199-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-175199-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MT-228 (BPN-0026709) is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder[1].
CAS Number
2404652-24-8
Product Name Alternative
BPN-0026709
UNSPSC
12352005
Target
Myosin
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.9
Smiles
O=C1[C@@]2(O)C(N(C3=CC(OC)=NC=C3)CC2)=NC4=C1C=C(C)C(C)=C4
Molecular Formula
C19H19N3O3
Molecular Weight
337.37
References & Citations
[1]Radnai L, et al. Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential. bioRxiv [Preprint]. 2024 Oct 12:2024.10.07.617018.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(3aS)-3a-hydroxy-1-(2-methoxy-4-pyridinyl)-6,7-dimethyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
CAS Number2404652-24-8
PubChem CID147430085
IUPAC Name(3aS)-3a-hydroxy-1-(2-methoxy-4-pyridinyl)-6,7-dimethyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Molecular FormulaC19H19N3O3
Molecular Weight337.4
XLogP2
Topological Polar Surface Area75
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity580
SMILES
CC1=CC2=C(C=C1C)N=C3[C@](C2=O)(CCN3C4=CC(=NC=C4)OC)O
InChI
InChI=1S/C19H19N3O3/c1-11-8-14-15(9-12(11)2)21-18-19(24,17(14)23)5-7-22(18)13-4-6-20-16(10-13)25-3/h4,6,8-10,24H,5,7H2,1-3H3/t19-/m1/s1
InChIKey
DUDYNUXUMAKUPK-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of (3aS)-3a-hydroxy-1-(2-methoxy-4-pyridinyl)-6,7-dimethyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
CAS: 2404652-24-8
CID: 147430085
Formula: C19H19N3O3
MW: 337.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.4
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass337.14264148
Monoisotopic Mass337.14264148
Topological Polar Surface Area75 Ų
Heavy Atom Count25
Formal Charge0
Complexity580
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-P991404AMG-228
HY-W1008853CRBN ligand-228
HY-161802Antibacterial agent 228
HY-121820DMJ-I-228
HY-122562-01MT-802
HY-175188-01MT-110
HY-122249MT-7
HY-162677-01MT-1207
HY-128349MT-3014
HY-155395DDAN-MT

Alternative Products

CatalogName
T9901A-1596-01AMG-228
255307FK 228
B2633-5ML-228
299301APP 228 (Amyloid Precursor Protein 228)
468867-01XL 228
255856-01ML 228
2632-1XL-228
MBS5780709CPU-228
043-22HP 228
MO20015APP 228

Popular Products