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DMJ-I-228

CAT: 0804-HY-121820Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121820Size:1 Each
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Description
DMJ-I-228 is a CD4-mimetic. DMJ-I-228 binds to HIV-1 gp120 within the conserved Phe 43 cavity near the CD4-binding site, thereby blocking CD4 binding and inhibiting HIV-1 infection[1].
CAS Number
1374035-59-2
UNSPSC
12352005
Hazard Statement
H302-H372-H411
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dmj-i-228.html
Smiles
O=CO.O=C(N[C@@H]1[C@@H](NC(N)=N)CC2=C1C=CC=C2)C(NC3=CC=C(Cl)C(F)=C3)=O
Molecular Formula
C19H19ClFN5O4
Molecular Weight
435.84
Precautions
P260-P264-P273-P391-P501
References & Citations
[1]Madani N, et al. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun;88 (12) :6542-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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