CDK6/9-IN-2

CAT: 0804-HY-175013Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175013Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) . CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research[1].
CAS Number
[3068529-24-5]
UNSPSC
12352005
Target
CDK; Interleukin Related; STAT
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(NC4=CC=C(C=C4)N5CC[C@@H](C5)O)=N3)Cl
Molecular Formula
C25H30ClN7O
Molecular Weight
480.01
References & Citations
[1]Ru Y, et al. Dual CDK6 and CDK9 inhibitors as anti-psoriasis agents: Design, synthesis, and anti-inflammatory activity. Bioorg Med Chem Lett. 2025 Nov 1;127:130316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK6; CDK9; IL-1; IL-6; IL-8; STAT3

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