CDK6/9-IN-2

CAT: 0931-MF-0119022-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0119022-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3068529-24-5
Target
CDK|||Interleukin|||STAT
Related Pathways
Cell Cycle/Checkpoint|||Immunology/Inflammation|||Stem Cells|||JAK/STAT signaling
Bioactivity
CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-?/TNF-?-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.
Smiles
O[C@@H]1CN(C2=CC=C(NC3=NC(NC4=CC=C(C=C4)N5CCN(C)CC5)=NC=C3Cl)C=C2)CC1
Molecular Formula
C25H30ClN7O
Molecular Weight
480.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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