CDK6/9-IN-2

• Target:

  CDK|||Interleukin|||STAT

• Related Pathways:

  Cell Cycle/Checkpoint|||Immunology/Inflammation|||Stem Cells|||JAK/STAT signaling

• Bioactivity:

  CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-?/TNF-?-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.

• Smiles:

  O[C@@H]1CN(C2=CC=C(NC3=NC(NC4=CC=C(C=C4)N5CCN(C)CC5)=NC=C3Cl)C=C2)CC1

• Molecular Formula:

  C25H30ClN7O

• Molecular Weight:

  480.01

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3068529-24-5