BT-O2C

• Description:

  BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C can be used for research on cancer. (Pink: p300 Ligand (HY-174868) ; Blue: CRBN Ligand (HY-W023573) ; Black: Linker; CRBN Ligand+Linker (HY-174869) ) [1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; Histone Acetyltransferase; PROTACs

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C(N(CC1=CC=C(F)C=C1)[C@@H](C)C(F)(F)F)CN(C(N[C@]23C[C@@H](F)C4=C3C=CC(C5=CN(CC(NCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)N=C5)=C4)=O)C2=O

• Molecular Formula:

  C48H48F5N9O8

• Molecular Weight:

  973.94

• References & Citations:

  [1]Marsh GP, et al. Development of p300-targeting degraders with enhanced selectivity and onset of degradation. RSC Med Chem. 2025 Mar 3;16 (5) :2049-2060.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CBP/p300; Cereblon

• CAS Number:

  [3055107-34-8]