BT-Amide

CAT: 0804-HY-169953Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169953Size:1 Each
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Description
BT-Amide is the orally active inhibitor for Pyk2 kinase with IC50 of 44.69 nM. BT-Amide prevents glucocorticoid-induced bone loss, exhibits bone protective activity in C57BL/6 mouse[1].
UNSPSC
12352005
Target
Pyk2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Metabolic Disease
Smiles
ClC1=C(N=C(N=C1)NC2=CC=C(C=C2OC)NC(CCCCC(NCCCC(P(O)(O)=O)(P(O)(O)=O)O)=O)=O)NC3=C(C=CC=C3)C(NC)=O
Molecular Formula
C29H38ClN7O11P2
Molecular Weight
758.05
References & Citations
[1]Wang X, et al., Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss. J Med Chem. 2024 Nov 28;67 (22) :20708-20720.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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