BT-Amide

• Description :

  BT-Amide is the orally active inhibitor for Pyk2 kinase with IC50 of 44.69 nM. BT-Amide prevents glucocorticoid-induced bone loss, exhibits bone protective activity in C57BL/6 mouse[1].

• UNSPSC :

  12352005

• Target :

  Pyk2

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Field of Research :

  Metabolic Disease

• Smiles :

  ClC1=C(N=C(N=C1)NC2=CC=C(C=C2OC)NC(CCCCC(NCCCC(P(O)(O)=O)(P(O)(O)=O)O)=O)=O)NC3=C(C=CC=C3)C(NC)=O

• Molecular Formula :

  C29H38ClN7O11P2

• Molecular Weight :

  758.05

• References & Citations :

  [1]Wang X, et al., Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss. J Med Chem. 2024 Nov 28;67 (22) :20708-20720.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported