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BT-O2C

CAT: 0013-GTR19263097-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263097-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BT-O2C is a highly selective p300 PROTAC degrader that effectively reduces p300 levels in HAP1 cells. It exhibits significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines, with an IC50 of 152-221 nM, and notably decreases the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C is applicable in cancer research.
CAS Number
3055107-34-8
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C1[C@]2 (C=3C ([C@H] (F) C2) =CC (=CC3) C4=CN (CC (NCCCCCCCNC=5C=C6C (=CC5) C (=O) N (C6=O) C7C (=O) NC (=O) CC7) =O) N=C4) NC (=O) N1CC (N (CC8=CC=C (F) C=C8) [C@H] (C (F) (F) F) C) =O
Molecular Formula
C48H48F5N9O8
Molecular Weight
973.94
Storage Conditions
-20°C
Notes
For research use only.

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