AZ'320

• Description:

  AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation[1].

• UNSPSC:

  12352005

• Target:

  Necroptosis; RIP kinase

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O

• Molecular Formula:

  C20H20N2O4S2

• Molecular Weight:

  416.51

• References & Citations:

  [1]Soday L, et al. Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1. ACS Chem Biol. 2025 Jun 20.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported