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PROTAC HDAC degrader-2

CAT: 0804-HY-174444-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-174444-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs. (Pink: HDAC ligand : , Blue: E3 ligase CRBN Ligand (HY-131717), E3 ligase ligand-linker conjugate (HY-174473) ).
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCC(NCCCCCCN4CCC5=C(C6=CC=CC=C6N5CC7=CC=C(C=C7)C(NO)=O)C4)=O)=C3C2=O)=O
Molecular Formula
C40H43N7O7
Molecular Weight
733.81
References & Citations
[1]Zhai S, et al. Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders. J Med Chem. 2025 Jul 10;68 (13) :13793-13821.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; HDAC10; HDAC6

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