BRD4-IN-10

• Description:

  BRD4-IN-10 (Compound 31) is a selective BRD4 inhibitor with an IC50 of 13.5 nM. BRD4-IN-10 can exert anti-inflammatory and anti-fibrotic effects. BRD4-IN-10 also has good metabolic stability, pharmacokinetic properties and safety. BRD4-IN-10 can be used in the research of renal fibrosis diseases[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain

• Related Pathways:

  Epigenetics

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C1NC(C2(CCN(C3=NC(NC4=CC(N(C(C)C)[C@H](C)C(N5C)=O)=C5C=C4)=NC=C3)CC2)N1)=O

• Molecular Formula:

  C24H30N8O3

• Molecular Weight:

  478.55

• References & Citations:

  [1]Huang J, et al. Development of a potent BET inhibitor for the treatment of renal fibrosis. Eur J Med Chem. 2025 Oct 5;295:117822.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BRD4

• CAS Number:

  [3051852-76-4]