BRD4-IN-4

• Description:

  BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM) . BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/brd4-in-4.html

• Purity:

  96.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1C2=CC=CC3=C (S (=O) (N4CCCC4) =O) C=CC (N1CC) =C32

• Molecular Formula:

  C17H18N2O3S

• Molecular Weight:

  330.40

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2 (1H) -ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  304685-40-3