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KRAS-IN-5

CAT: 0931-T211066-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T211066-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3082412-00-5
Target
Ras
Related Pathways
MAPK
Bioactivity
KRAS-IN-5 (Compound Ex 6) is an orally active, selective inhibitor that targets KRAS mutants, including KRASG12D, KRASG12V, and KRASWT, with an impressive GNE IC50 value of 1.3 nM for KRASG12D. By inhibiting KRAS-mediated signaling pathways, such as reducing ERK phosphorylation, KRAS-IN-5 effectively prevents tumor cell proliferation. This compound holds potential for research into cancers associated with KRAS mutations, such as pancreatic cancer, colorectal cancer, and lung cancer.
Smiles
C(C)C1=C2C(=C3C(=CC2=CC=C1F)NN=C3C)C4=C(F)C=5C=6C(=N4)OC[C@]7(N(C6N=C(OC[C@@]89N(C[C@H](F)C8)CCC9)N5)CCCOC7)[H]
Molecular Formula
C35H36F3N7O3
Molecular Weight
659.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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