CPS-021

• Description :

  CPS-021 is a selective PAK4 PROTAC degrader with a DC50 of 50 nM. CPS-021 has potent antimigratory and invasive activity and significantly suppresses the invasion and metastasis of tumor cells in A549-luc lung metastasis mice model[1]. Pink: PAK4 ligand (HY-174822) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker

• UNSPSC :

  12352005

• Target :

  Cadherin; PAK; PROTACs

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; PROTAC

• Field of Research :

  Cancer

• Smiles :

  O=C(N1CCN(CC1)CCCCCCCC(N2CCN(CC2)CCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)C(C6=CC=C(C#CC7(O)CCCCC7)C=C86)=CN8C9=NC(N)=NC=C9

• Molecular Formula :

  C52H63N11O7

• Molecular Weight :

  954.13

• References & Citations :

  [1]Wang H, et al. Design, Synthesis, and Biological Evaluation of Selective PAK4 Degrader for the Treatment of Lung Tumor Metastasis. J Med Chem. 2025 Jun 12;68 (11) :11231-11269.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PAK4