CPS-11

• Description :

  CPS-11 (N- (Hydroxymethyl) thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

• Product Name Alternative :

  N- (Hydroxymethyl) thalidomide

• UNSPSC :

  12352005

• Target :

  NF-κB; Nuclear Factor of activated T Cells (NFAT) ; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cps-11.html

• Purity :

  99.39

• Smiles :

  O=C1N(C(C2=C1C=CC=C2)=O)C(C(N3CO)=O)CCC3=O

• Molecular Formula :

  C14H12N2O5

• Molecular Weight :

  288.26

• References & Citations :

  [1]Aragon-Ching JB, et al. Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov. 2007 Jun;2 (2) :167-74. |[2]Warfel NA, et al. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res. 2006 Jun 1;12 (11 Pt 1) :3502-9.|[3]Ge Y, et al. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108 (13) :4126-35.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [145945-21-7]