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CPS-11

CAT: 0804-HY-117987-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-117987-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPS-11 (N- (Hydroxymethyl) thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].
CAS Number
[145945-21-7]
Product Name Alternative
N- (Hydroxymethyl) thalidomide
UNSPSC
12352005
Target
NF-κB; Nuclear Factor of activated T Cells (NFAT) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cps-11.html
Purity
99.39
Smiles
O=C1N(C(C2=C1C=CC=C2)=O)C(C(N3CO)=O)CCC3=O
Molecular Formula
C14H12N2O5
Molecular Weight
288.26
References & Citations
[1]Aragon-Ching JB, et al. Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov. 2007 Jun;2 (2) :167-74. |[2]Warfel NA, et al. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res. 2006 Jun 1;12 (11 Pt 1) :3502-9.|[3]Ge Y, et al. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108 (13) :4126-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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