TP-021

• Description:

  TP-021 (BCL6-IN-8c), a chemical probe, is a potent and orally active B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay[1].

• Product Name Alternative:

  BCL6-IN-8c

• UNSPSC:

  12352005

• Target:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tp-021.html

• Concentration:

  10mM

• Purity:

  99.14

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C1NC2=C(CC1)C=C(C=C2)NC3=CC(OC4CCOCC4)=C(C=C3Cl)[N+]([O-])=O

• Molecular Formula:

  C20H20ClN3O5

• Molecular Weight:

  417.84

• References & Citations:

  [1]Yasui T, et al. Discovery of a novel B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor by utilizing structure-based drug design. Bioorg Med Chem. 2017 Sep 1;25 (17) :4876-4886.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2130878-25-8]