TP-021

• Description :

  TP-021 (BCL6-IN-8c), a chemical probe, is a potent and orally active B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay[1].

• Product Name Alternative :

  BCL6-IN-8c

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tp-021.html

• Concentration :

  10mM

• Purity :

  99.14

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C1NC2=C(CC1)C=C(C=C2)NC3=CC(OC4CCOCC4)=C(C=C3Cl)[N+]([O-])=O

• Molecular Formula :

  C20H20ClN3O5

• Molecular Weight :

  417.84

• References & Citations :

  [1]Yasui T, et al. Discovery of a novel B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor by utilizing structure-based drug design. Bioorg Med Chem. 2017 Sep 1;25 (17) :4876-4886.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2130878-25-8]