Anticancer agent 271

• Description:

  Anticancer agent 271 (compound 5C) has antiproliferative activity against lung (A549), colon (Caco-2) cancer cell lines, and human lung fibroblast (WI38) with an IC50 value of 9.18 μM on A549 cells. Anticancer agent 271 downregulates PI3K and mTOR gene expression that can be used for cancer research[1].

• UNSPSC:

  12352005

• Target:

  EGFR; mTOR; PI3K

• Related Pathways:

  JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  CC(C(C=C1)=CC=C1N(N=N2)C=C2COC(C=CC=C3)=C3C4=NC(C5=CC=C(C(F)(F)F)C=C5)=NO4)=O

• Molecular Formula:

  C26H18F3N5O3

• Molecular Weight:

  505.45

• References & Citations:

  [1]Mohammed Salah Ayoup, et al. Investigating the Anticancer Activity of Novel 1,2,4-Oxadiazole-Linked 1,2,3-Triazole Moieties via EGFR/pI3K/mTOR Cascade Down-Regulation. Polycyclic Aromatic Compounds. 26 Feb 2025.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported