Anticancer agent 239

CAT: 0931-MF-0117438-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0117438-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis|||Ferroptosis|||DNA/RNA Synthesis|||Telomerase
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Apoptosis
Bioactivity
Anticanceragent 239 (Compound 5) is a ligand for the hTERT promoter G-quadruplex DNA structure (hTERT G4) with a dissociation constant (Kd) of 1.1 ?M and reduces hTERT expression. It decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Additionally, Anticanceragent 239 causes mitochondrial dysfunction, disrupts iron metabolism, and activates ferroptosis in cancer cells. It also inhibits tumor growth in MDA-MB-231 xenograft mouse models.
Molecular Formula
C37H36F3IN4S
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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