Anticancer agent 192

CAT: 0804-HY-157931Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157931Size:1 Each
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Description
Anticancer agent 192 (compound XXI) is a steroid-based histamine H3 receptor antagonist with no affinity for muscarinics and hERG. Anticancer agent 192 is quite stable in human and rat liver microsomes. Anticancer agent 192 can improve the cognitive level and reduce the degree of addiction in rats in the in vivo addiction test[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-192.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CC[C@@]3(NC(CC[C@]3([C@@]1(CCC4=C2C=CC(OCCCN5CCC[C@H]5C)=C4)[H])[H])=O)C
Molecular Formula
C26H38N2O2
Molecular Weight
410.59
References & Citations
[1]Ledneczki I, et al. Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists. J Med Chem. 2024 Feb 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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