Anticancer agent 192

• Description:

  Anticancer agent 192 (compound XXI) is a steroid-based histamine H3 receptor antagonist with no affinity for muscarinics and hERG. Anticancer agent 192 is quite stable in human and rat liver microsomes. Anticancer agent 192 can improve the cognitive level and reduce the degree of addiction in rats in the in vivo addiction test[1].

• UNSPSC:

  12352005

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-192.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12CC[C@@]3(NC(CC[C@]3([C@@]1(CCC4=C2C=CC(OCCCN5CCC[C@H]5C)=C4)[H])[H])=O)C

• Molecular Formula:

  C26H38N2O2

• Molecular Weight:

  410.59

• References & Citations:

  [1]Ledneczki I, et al. Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists. J Med Chem. 2024 Feb 23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4