Anticancer agent 147

• Description:

  Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

• UNSPSC:

  12352005

• Target:

  Ferroptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-147.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC (CCC[C@]1 ([H]) [C@]2 ([H]) [C@]3 ([H]) [C@@] (CCCN3CCC2) ([H]) CN1CC (C4=C5C=CC=C4) =CN5CC6=CC=C (Br) C=C6) =O

• Molecular Formula:

  C32H40BrN3O2

• Molecular Weight:

  578.58

• References & Citations:

  [1]Tian K, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. Cell Death Discov. 2023 Aug 14;9 (1) :296..

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2241283-11-2