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Anticancer agent 147

CAT: 0804-HY-155158Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155158Size:1 Each
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Description
Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].
CAS Number
[2241283-11-2]
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-147.html
Solubility
10 mM in DMSO
Smiles
COC(CCC[C@]1([H])[C@]2([H])[C@]3([H])[C@@](CCCN3CCC2)([H])CN1CC(C4=C5C=CC=C4)=CN5CC6=CC=C(Br)C=C6)=O
Molecular Formula
C32H40BrN3O2
Molecular Weight
578.58
References & Citations
[1]Tian K, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. Cell Death Discov. 2023 Aug 14;9 (1) :296..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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