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MAGL-IN-13

CAT: 0804-HY-163202Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163202Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL, with IC50 values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. [1].
UNSPSC
12352005
Target
Calcium Channel; MAGL
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/magl-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H]([C@H](N1C2CCN(CC2)C(N3N=NC4=C3C=CC=C4)=O)C5=CC6=C(C=C5)OCO6)C7=CC=C(C=C7)F
Molecular Formula
C28H24FN5O4
Molecular Weight
513.52
References & Citations
[1]Butini S et al., Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J Med Chem. 2024 Jan 19. doi: 10.1021/acs.jmedchem.3c01278.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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