ABCA1 inducer 1

• Description:

  ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4[1].

• UNSPSC:

  12352005

• Target:

  Apolipoprotein

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/abca1-inducer-1.html

• Smiles:

  CCOC (C1=CC (NC (C2=C (C=C (S2) Cl) S (=O) (N (C3=CC (OC) =C (C=C3) OCC) C) =O) =O) =CC (Cl) =C1) =O

• Molecular Formula:

  C24H24Cl2N2O7S2

• Molecular Weight:

  587.49

• References & Citations:

  [1]Velma GR, et al. Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4. J Med Chem. 2024 Sep 12;67 (17) :15061-15079.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2839627-76-6