ABCA1 inducer 1

• Description :

  ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4[1].

• UNSPSC :

  12352005

• Target :

  Apolipoprotein

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/abca1-inducer-1.html

• Smiles :

  CCOC(C1=CC(NC(C2=C(C=C(S2)Cl)S(=O)(N(C3=CC(OC)=C(C=C3)OCC)C)=O)=O)=CC(Cl)=C1)=O

• Molecular Formula :

  C24H24Cl2N2O7S2

• Molecular Weight :

  587.49

• References & Citations :

  [1]Velma GR, et al. Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4. J Med Chem. 2024 Sep 12;67 (17) :15061-15079.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2839627-76-6]