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CDK2-IN-42

CAT: 0804-HY-173147Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173147Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2-IN-42 (Compound H63) is a CDK12 inhibitor with an IC50 value of 10 nM. CDK2-IN-42 has anti-ESCC (Esophageal Squamous Cell Carcinoma) cell activity. It can block transcriptional elongation, downregulate the core genes in the G1 phase to induce cell cycle arrest, and alter the CDK12-ATM/ATR-CHEK1/CHEK2 signaling axis, resulting in DNA damage. CDK2-IN-42 can effectively inhibit tumor growth in a xenograft mouse model of human ESCC KYSE150. CDK2-IN-42 holds great promise for research in the field of cancer[1].
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=CC(NC3=NC=CC(C4=CN=C(NC)S4)=N3)=C2
Molecular Formula
C19H15N7O4S
Molecular Weight
437.43
References & Citations
[1]Cao Y, et al. Discovery of 4- (2- (methylamino) thiazol-5-yl) pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma. Bioorg Chem. 2025 May;158:108302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12

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