CDK2-IN-52

• Description:

  CDK2-IN-52 (Compound Cpb No 39) is a selective cyclin-dependent kinase 2 (CDK2) inhibitor with a DC50 value of 1-10 nM. CDK2-IN-52 induces cell cycle arrest and suppresses tumor cell proliferation. CDK2-IN-52 is promising for research of CDK2-overexpressing malignancies such as breast and ovarian cancers[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C1NC(CCN1C2=NN(C)C3=C2C=CC(C4CCN(CC5CCN(CC5)C6=CC=CC(S(=O)(N7CCC(CC7)NC8=NC=C(C=N8)Cl)=O)=C6)CC4)=C3)=O

• Molecular Formula:

  C38H47ClN10O4S

• Molecular Weight:

  775.36

• References & Citations:

  [1]Zhiyong Yu, et al. Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849A1. 2024-05-16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK2

• CAS Number:

  [3038638-82-0]