Products for Research Use Only
RegisterLogin

CDK12/13-IN-3

CAT: 0804-HY-173059-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-173059-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK12/13-IN-3 (Compound 12b) is the orally active inhibitor for CDK that inhibits CDK12 and CDK13 with IC50 of 107.4 nM and 79.4 nM. CDK12/13-IN-3 inhibits the phosphorylation of Ser2 on the CTD of RNA polymerase II, induces DNA damage, and downregulates the gene expression of DNA damage response (DDR) . CDK12/13-IN-3 exhibits antiproliferative activity against multiple cancer cells with IC50 of nanomolar levels. CDK12/13-IN-3 exhibits antitumor effect in mouse models, exhibits good pharmacokinetic properties with an oral bioavailability of 53.6%[1].
CAS Number
3029608-57-6
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
COC1=NC(N[C@@H]2CCN(C3=NC=NC4=C3CCN(C(C=C)=O)C4)C2)=NC=C1Cl
Molecular Formula
C19H22ClN7O2
Molecular Weight
415.88
References & Citations
[1]Lu H, et al., Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of Tumors. J Med Chem. 2025 Feb 27;68 (4) :4148-4167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK13

Related Products

CatalogName
HY-160284CDK12/13-IN-1
HY-173042CDK12/13-IN-2
HY-168163CDK12/13 ligand 1
HY-168658CDK12/13 ligand 2
HY-151110-01PROTAC CDK12/13 Degrader-1
HY-112261-01CDK12-IN-3
HY-151110A-01PROTAC CDK12/13 Degrader-1 (TFA)
HY-177786CDK12 ligand-3
HY-171786CDK12-IN-8
HY-139329-01CDK12-IN-6

Alternative Products

CatalogName
T206377-01CDK12/13-IN-3
GTR19277078-01CDK12/13 ligand 3
GTR19249505-01CDK12/13-IN-2
GTR19235957-01CDK12/13-IN-1
T201159-01CDK12/13 ligand 1
T64284-01PROTAC CDK12/13 Degrader-1
TBI4864-25MGSR-4835, CDK12/13 inhibitor
VND18450-01CDK12-IN-3
A23984-10PROTAC CDK12/13 Degrader-1 10mg
A23984-5PROTAC CDK12/13 Degrader-1 5mg

Popular Products