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CDK12/13 ligand 1

CAT: 0804-HY-168163Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168163Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK-IN-29 (compound 4c) has a certain inhibitory effect on tyrosine protein kinases ALK, CDK2/CyclinE1 and FAK, among which the strongest inhibitory effect on ALK kinase is 40.63% at a concentration of 10 μM. ALK-IN-29 can be used for anti-cancer research[1].
CAS Number
2244986-40-9
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk12-13-ligand-1.html
Smiles
O=C(N([C@@H]1CC[C@H](CC1)NC2=CC=C(C=N2)C#N)C3=CC=C(Br)C=C3)NCC4=CC=CC=C4
Molecular Formula
C26H26BrN5O
Molecular Weight
504.42
References & Citations
[1]Zhou L, et al. Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. J Med Chem. 2024 Oct 24;67 (20) :18247-18264.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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