FGFR-IN-18

• Description:

  FGFR-IN-18 (Compound KF7) is a lysine-targeting FGFR covalent inhibitor, with IC50s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM) . FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs) [1].

• UNSPSC:

  12352211

• Target:

  FGFR

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  COC1=CC(CCC2=CC(NC3=NC(NCC4=CC=CC(CNC5=C(C(C5=O)=O)OC)=C4)=NC(NCCOC)=N3)=NN2)=CC(OC)=C1

• Molecular Formula:

  C32H37N9O6

• Molecular Weight:

  643.69

• References & Citations:

  [1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7;147 (18) :15469-15481.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported