SDH-IN-26

• Description:

  SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC50 value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi[1].

• UNSPSC:

  12352211

• Target:

  Apoptosis; Fungal; Succinate Dehydrogenase

• Related Pathways:

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=C(C1=CSC(N/N=C2C(C)=CC[C@@H](C(C)=C)C/2)=N1)NNC3=CC=C(F)C=C3

• Molecular Formula:

  C20H22FN5OS

• Molecular Weight:

  399.48

• References & Citations:

  [1]Chen H, et al. Design, Synthesis, Antifungal Evaluation, and Action Mechanism of Novel l-Carvone-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2025 Apr 16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported