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SDH-IN-26

CAT: 0804-HY-172804Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172804Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC50 value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi[1].
UNSPSC
12352211
Target
Apoptosis; Fungal; Succinate Dehydrogenase
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(C1=CSC(N/N=C2C(C)=CC[C@@H](C(C)=C)C/2)=N1)NNC3=CC=C(F)C=C3
Molecular Formula
C20H22FN5OS
Molecular Weight
399.48
References & Citations
[1]Chen H, et al. Design, Synthesis, Antifungal Evaluation, and Action Mechanism of Novel l-Carvone-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2025 Apr 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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