SDH-IN-27

• Description:

  SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L) . SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L) . SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi[1].

• UNSPSC:

  12352005

• Target:

  Fungal

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  CCC1=C(N2C(CCl)=C(C(NC3=NC=CC=N3)=O)C=N2)C=CC=C1

• Molecular Formula:

  C17H16ClN5O

• Molecular Weight:

  341.79

• References & Citations:

  [1]Chen K, et al. Synthesis and Activity of Novel Pyrazole/Pyrrole Carboxamides Containing a Dinitrogen Six-Membered Heterocyclic as Succinate Dehydrogenase and Ergosterol Biosynthesis Inhibitors against Colletotrichum camelliae. J Agric Food Chem. 2025 May 7;73 (18) :10914-10922.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported