SDH-IN-25

• Description:

  SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L) . SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43) . SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control[1].

• UNSPSC:

  12352101

• Target:

  Fungal; MMP; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Infection

• Smiles:

  ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1

• Molecular Formula:

  C19H15BrCl2N2O4

• Molecular Weight:

  486.14

• References & Citations:

  [1]Wang FY, Xu D, He HW, Lin GT, Zhou H, Liu X, Xu G. Discovery of α-Methylene-γ-Butyrolactone Derivatives with Hydrazide Moieties as Novel Fungicidal Agents. J Agric Food Chem. 2025 Apr 23;73 (16) :9521-9532.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3052432-15-9]