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SDH-IN-25

CAT: 0804-HY-172777Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172777Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control[1].
CAS Number
3052432-15-9
UNSPSC
12352101
Target
Fungal; MMP; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
ClC1=CC(Cl)=C(OCC(NNC2=CC=C(Br)C=C2)=O)C(C3OC(C(C3)=C)=O)=C1
Molecular Formula
C19H15BrCl2N2O4
Molecular Weight
486.14
References & Citations
[1]Wang FY, Xu D, He HW, Lin GT, Zhou H, Liu X, Xu G. Discovery of α-Methylene-γ-Butyrolactone Derivatives with Hydrazide Moieties as Novel Fungicidal Agents. J Agric Food Chem. 2025 Apr 23;73 (16) :9521-9532.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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