PSB-24000

• Description :

  PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM against human CD73 (Ki= 481 nM at membrane-bound CD73 in triple-negative breast cancer cells) . PSB-24000 interferes with CD73's recognition and action on the substrate AMP, and prevents the generation of immunosuppressive and cancer-promoting adenosine from AMP. PSB-24000 is promising for research of cancers[1].

• UNSPSC :

  12352005

• Target :

  CD73

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=P(CP(O)(O)=O)(OCCCCCCN1C=NC2=C(N(CC3=CC=CC=C3)C)N=C(Cl)N=C12)O

• Molecular Formula :

  C20H28ClN5O6P2

• Molecular Weight :

  531.87

• References & Citations :

  [1]Federico S, et al. Acyclic purine and pyrimidine nucleotide analogs as ecto-5’-nucleotidase (CD73) inhibitors[J]. European Journal of Medicinal Chemistry, 2025: 117653.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported