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EGFR-IN-110

CAT: 0804-HY-158154Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158154Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-110 (Compound 6) is a covalent EGFR inhibitor, with pIC50 values of 9.2 and 8.7 for EGFR enzyme and EGFR cell, respectively. EGFR-IN-110 shows high EGFR potency and good kinase selectivity[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-110.html
Solubility
10 mM in DMSO
Smiles
C=CC1=NC=CC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)=C1
Molecular Formula
C22H16ClFN4O2
Molecular Weight
422.84
References & Citations
[1]Pemberton N, et al. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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