EGFR-IN-110

• UNSPSC Description:

  EGFR-IN-110 (Compound 6) is a covalent EGFR inhibitor, with pIC50 values of 9.2 and 8.7 for EGFR enzyme and EGFR cell, respectively. EGFR-IN-110 shows high EGFR potency and good kinase selectivity[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/egfr-in-110.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC1=NC=CC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)=C1

• Molecular Weight:

  422.84

• References & Citations:

  [1]Pemberton N, et al. Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS Medicinal Chemistry Letters, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported