PPAR agonist 6

CAT: 0804-HY-172792Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172792Size:1 Each
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Description
PPAR agonist 6 (compound 5a) is an agonist of PPAR with EC50 values of 3.6 μM, 2.6 μM, and 2.7 μM for PPARα, PPARβ/δ, and PPARγ, respectively. PPAR agonist 6 represses the transactivation of the TNFα-dependent NF-κB-driven reporter in L929 cells[1].
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(OCC)CC/C(C)=C/CCC1N(C)C2=C(C=C(OCC3=CC=CC=C3)C=C2)CC1
Molecular Formula
C27H35NO3
Molecular Weight
421.57
References & Citations
[1]Carlos Villarroel-Vicente, et al. Development of 2- and 3-prenylated quinolines and tetrahydroquinolines with PPAR activity: From hit to lead and a novel pan-PPAR agonist as a potential candidate for metabolic syndrome. Bioorg Chem. 2025 Jun 15:160:108450.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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