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NLRP3-IN-78

CAT: 0804-HY-172788Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172788Size:1 Each
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Description
NLRP3-IN-78 (compound 21) is a NLRP3 inhibitor with the inhibition rate of 46.72% in GSDMD-induced pyroptosis at 5 μM. NLRP3-IN-78 binds to the NLRP3 protein and inhibits GSDMD-NT oligomerization. NLRP3-IN-78 also inhibits GSDMD cleavage, and upstream NF-κB signaling, demonstrating its anti-inflammatory activity[1].
CAS Number
477546-27-3
UNSPSC
12352211
Target
NF-κB; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
ClC1=CC(C2=CSC(NC(C3=CC=C([N+]([O-])=O)O3)=O)=N2)=C(Cl)S1
Molecular Formula
C12H5Cl2N3O4S2
Molecular Weight
390.22
References & Citations
[1]Dai Z, et al. Discovery of a novel Thiazole amide inhibitor of Inflammasome and Pyroptosis pathways. Bioorg Chem. 2025 Jun 15;160:108477.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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