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NLRP3-IN-78

CAT: 0931-T206735-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206735-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
477546-27-3
Target
Pyroptosis, NF-κB
Related Pathways
Apoptosis, Immunology/Inflammation, NF-κB
Bioactivity
NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.
Smiles
O=C(NC1=NC(=CS1)C=2C=C(Cl)SC2Cl)C=3OC(=CC3)N(=O)=O
Molecular Formula
C12H5Cl2N3O4S2
Molecular Weight
390.222
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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