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NLRP3-IN-33

CAT: 0804-HY-162402Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162402Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-33 (Compound 12o) is a blood-brain barrier permeable inhibitor of AChE and BChE, with IC50 values of 1.02 μM and 7.03 μM against hAChE and hBChE respectively. NLRP3-IN-33 possesses antioxidant, anti-inflammatory, and metal chelating activities, making it a potential candidate for research in Alzheimer's disease (AD) [1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-33.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(NC1=C2C=CC=NC2=C(O)C=C1)=O)/C=C/C3=CC=C(O)C(OC)=C3
Molecular Formula
C21H19N3O5
Molecular Weight
393.39
References & Citations
[1]Singh G, et al. Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer's Disease. ACS Chem Neurosci. 2024;15 (7) :1388-1414.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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