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NLRP3-IN-26

CAT: 0804-HY-162013Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162013Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC50 of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study[1].
CAS Number
2927413-30-5
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-26.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1CC2=CC=C(S(=O)(NCCC)=O)C=C2C1)CC3=CC(Cl)=CC=C3OCCOC)C4=CC5=C(C=CC=C5)O4
Molecular Formula
C31H33ClN2O6S
Molecular Weight
597.12
References & Citations
[1]Sun S, et al. Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis. J Med Chem. 2023;66 (23) :16141-16167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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