BS-181

CAT: 0804-HY-13266Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13266Size:5 mg
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Description
BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237) . BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6) . BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].
CAS Number
[1092443-52-1]
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BS-181.html
Purity
98.10
Smiles
CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C
Molecular Formula
C22H32N6
Molecular Weight
380.53
References & Citations
[1]Ali S et al. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 Aug 1;69 (15) :6208-15.|[2]Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Citation 01
Biochem Biophys Res Commun. 2019 Jun 11;513 (4) :967-973.|Cell Rep. 2017 Dec 5;21 (10) :2796-2812.|Theranostics. 2017 Apr 20;7 (7) :1914-1927.|Int J Biol Macromol. 2024 Dec 27:139117.|Universidade de Lisboa. 2021 Dec 21.

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