Biotin-BS

CAT: 0804-HY-111879Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-111879Size:1 Each

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Description

Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].

UNSPSC

12352005

Target

SNIPERs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/biotin-bs.html

Solubility

10 mM in DMSO

Smiles

N[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NCCOCCOCCOCCOCCOCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)=O)O)CC3=CC=CC=C3

Molecular Formula

C38H64N6O10S

Molecular Weight

797.01

References & Citations

[1]Ohoka N, et al. SNIPER (TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108 (5) :1032-1041.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-13266A-01	BS-181 (hydrochloride)
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HY-W753222	(aS, bS) -rel-Bedaquiline-d6
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T17706-01	BzNH-BS
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MBS3600348-01	BS-181
T207422-01	BS-153
MBS132771-01	BS 181
G2300	BS Fixative
N01127-01	Naphthol AS-BS

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