Biotin-BS

• Description :

  Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].

• UNSPSC :

  12352005

• Target :

  SNIPERs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/biotin-bs.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NCCOCCOCCOCCOCCOCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)=O)O)CC3=CC=CC=C3

• Molecular Formula :

  C38H64N6O10S

• Molecular Weight :

  797.01

• References & Citations :

  [1]Ohoka N, et al. SNIPER (TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108 (5) :1032-1041.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported