Biotin-BS

• UNSPSC Description:

  Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase[1].

• Target Antigen:

  SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/biotin-bs.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@@H]([C@@H](C(N[C@@H](CC(C)C)C(NCCOCCOCCOCCOCCOCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)=O)O)CC3=CC=CC=C3

• Molecular Weight:

  797.01

• References & Citations:

  [1]Ohoka N, et al. SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108(5):1032-1041.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported