APD-94

• Description :

  APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; BMI1; Microtubule/Tubulin

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  COC1=CC(O)=C(C2=NC(N)=NC=C2OC3=CC(OC)=CC=C3)C=C1

• Molecular Formula :

  C18H17N3O4

• Molecular Weight :

  339.35

• References & Citations :

  [1]Gao L, et al. A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation. Biochem Pharmacol. 2025 Mar;233:116783.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [877810-03-2]