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APD-94

CAT: 0804-HY-172617Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172617Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study[1].
CAS Number
[877810-03-2]
UNSPSC
12352005
Target
Apoptosis; BMI1; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt
Field of Research
Cancer
Smiles
COC1=CC(O)=C(C2=NC(N)=NC=C2OC3=CC(OC)=CC=C3)C=C1
Molecular Formula
C18H17N3O4
Molecular Weight
339.35
References & Citations
[1]Gao L, et al. A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation. Biochem Pharmacol. 2025 Mar;233:116783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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