APD-94

• Target :

  Microtubule Associated|||Apoptosis|||BMI-1

• Related Pathways :

  Apoptosis|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling

• Bioactivity :

  APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.

• Smiles :

  OC=1C=C(OC)C=CC1C2=NC(=NC=C2OC3=CC=CC(OC)=C3)N

• Molecular Formula :

  C18H17N3O4

• Molecular Weight :

  339.345

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  877810-03-2