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APD-94

CAT: 931-T206828-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
877810-03-2
Target
Microtubule Associated|||Apoptosis|||BMI-1
Related Pathways
Apoptosis|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling
Bioactivity
APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.
Smiles
OC=1C=C(OC)C=CC1C2=NC(=NC=C2OC3=CC=CC(OC)=C3)N
Molecular Formula
C18H17N3O4
Molecular Weight
339.345
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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