Products for Research Use Only
RegisterLogin

APD 668

CAT: 0013-GTR19161518-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19161518-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. (In Vitro) :APD668 increases adenylate cyclase activation in HEK293 cells transfected with human GPR119 in a concentration-dependent manner with an EC50 of 23 nM.APD668 is highly bound to plasma proteins of male and female cynomolgus monkeys and humans (99%), but is less extensively bound to male (93.0%) and female (96.6%) rats. (In Vivo) :APD668 (10-30 mg/kg; p.o. once daily for 8 weeks) significantly reduces blood glucose and glycated hemoglobin (HbA1c) levels, with no desensitization of the acute drug response.APD668 (1-10 mg/kg; a single p.o.) markedly reduces blood glucose levels during oral glucose tolerance test in a dose-dependent manner in mice.APD668 (0.08 mg/kg/min; i.v.) shows no effect during euglycemic condition, but significantly stimulates insulin release when blood glucose levels are raised to approximately 300 mg/dl in a hyperglycemic clamp model in the Sprague-Dawley rat.APD668 (p.o.) exhibits rapid to moderate absorption (tmax≤2 h) in mice, rats, and monkeys, but slower in dogs (tmax=6 h), and moderate to good absolute oral bioavailability (44-79%) in mice, rats, and monkeys, but lower in dogs (22%) .
CAS Number
832714-46-2
Product Name Alternative
JNJ-28630368
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
O=C (N1CCC (OC2=C3C (N (C4=CC=C (S (=O) (C) =O) C=C4F) N=C3) =NC=N2) CC1) OC (C) C
Molecular Formula
C21H24FN5O5S
Molecular Weight
477.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Isopropyl 4- ((1- (2-fluoro-4- (methylsulfonyl) phenyl) -1H-pyrazolo[3,4-d]pyrimidin-4-yl) oxy) piperidine-1-carboxylate .

Chemical Information

Apd-668

APD668 is a novel, highly potent and orally active glucose-dependent insulinotropic receptor (GDIR) agonist intended to more efficiently stimulate insulin release by beta cells in response to elevated blood glucose levels, and to also avoid hypoglycemia.

CAS Number832714-46-2
PubChem CID11705608
IUPAC Namepropan-2-yl 4-[1-(2-fluoro-4-methylsulfonylphenyl)pyrazolo[5,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate
Molecular FormulaC21H24FN5O5S
Molecular Weight477.5
XLogP2.7
Topological Polar Surface Area125
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity788
SMILES
CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=NN3C4=C(C=C(C=C4)S(=O)(=O)C)F
InChI
InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
InChIKey
XTRUQJBVQBUKSQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Apd-668
CAS: 832714-46-2
CID: 11705608
Formula: C21H24FN5O5S
MW: 477.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight477.5
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass477.14821822
Monoisotopic Mass477.14821822
Topological Polar Surface Area125 Ų
Heavy Atom Count33
Formal Charge0
Complexity788
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19234199-01APD-916
GTR19258261-01APD-94
GTR19209113-01APD-916 dicitrate
GTR19234623-01SOMCL-668
GTR19276788-01CRBN ligand-668
GTR18085786Anti-APP (Ab-668)
GTR19226483-01IRBP (668-687) (TFA)
GTR18056046-01APP (Ab-668) Antibody
GTR19293971-01Rno-miR-668 miRNA Agomir
GTR19293970-01Rno-miR-668 miRNA Antagomir

Alternative Products

CatalogName
TBI3024-25MGAc-Leu-Leu-Nle-CHO (ALLN), Calpain inhibitor
TBS10340-0.5MGInVivo Mouse IgG1 Isotype Control Antibody
TBS10338-0.5MGInVivo Anti-Mouse CD161/KLRB1/NK1.1 Antibody
TBS10336-1MGInVivoMAb Anti-Human Flt3 ligand/FLT3LG Antibody
TBS10334-0.5MGInVivo Anti-Human CDH17/Cadherin-17 Monoclonal Antibody
TBS10333-1MGInVivo Anti-Phosphotyrosine Monoclonal Antibody
TBS42064-100Clostridium butyricum qPCR Detection Kit
TBI5887-25MGRo 5-3335, RUNX1 inhibitor
TBI5778-5MGSBI-797812, NAMPT activator
TBI5468-25MGPyrintegrin, ß1-integrin agonist

Popular Products