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ROCK/HDAC-IN-2

CAT: 0804-HY-172177Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172177Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROCK/HDAC-IN-2 (Compound C-9) is a ROCK/HDAC inhibitor, with IC50 values of 0.185 µM, 0.8 µM, and 0.7 µM for HDAC6, ROCK1, and ROCK2, respectively. ROCK/HDAC-IN-2 can induce apoptosis and changes in mitochondrial membrane potential in cancer cells, demonstrating significant antitumor activity. ROCK/HDAC-IN-2 can be used in the research of pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC) [1].
UNSPSC
12352211
Target
Apoptosis; HDAC; ROCK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(NO)CCCCCCCN1CCCN(CC1)S(=O)(C2=CC=CC3=C2C=CN=C3)=O
Molecular Formula
C22H32N4O4S
Molecular Weight
448.58
References & Citations
[1]Beljkas M, et al. Pioneering first-in-class HDAC-ROCK inhibitors as potential multitarget anticancer agents. Future Med Chem. 2025 Feb;17 (4) :393-407.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; ROCK1; ROCK2

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