LSD1-IN-39

• Description:

  LSD1-IN-39 (Compound 14) is a reversible inhibitor for LSD1 with an IC50 of 0.18 μM. LSD1-IN-39 exhibits broad-spectrum anti-proliferative activity against cancer cells, inhibits the cell migration of HepG2 and inhibits the epithelial-mesenchymal transition. LSD1-IN-39 exhibits antitumor activity in mouse models[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C(CCN1C(CCCC1=O)=O)N(C2=CC(OC)=C(C(OC)=C2)OC)CC3=CC=C(C=C3)OC

• Molecular Formula:

  C25H30N2O7

• Molecular Weight:

  470.51

• References & Citations:

  [1]Zhang XS, et al., Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects in vitro and in vivo. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2466093.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1

• CAS Number:

  [3024554-34-2]