AMPK-IN-6

• Description:

  AMPK-IN-6 (compound 13a) is potent AMPK inhibitor with an IC50 value of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 shows antiproliferative activity. AMPK-IN-6 has the potential for the research of pulmonary arterial hypertension[1].

• UNSPSC:

  12352005

• Target:

  AMPK; Apoptosis; Autophagy

• Related Pathways:

  Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  N[C@@H]1CC[C@@H](CC1)NC2=C(C(NC=C2)=O)C3=NC4=C(N3)C=CC(F)=C4

• Molecular Formula:

  C18H20FN5O

• Molecular Weight:

  341.38

• References & Citations:

  [1]Tan W, et al. A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model. Eur J Med Chem. 2025 Jan 12;286:117266.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AMPK