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AMPK-IN-1

CAT: 0804-HY-120904-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120904-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1) . AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3].
CAS Number
1219739-95-3
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-in-1.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(C=C4)C=CN5C)C=C3N2)=CC=C1C
Molecular Formula
C24H18ClN3O3
Molecular Weight
431.87
References & Citations
[1]Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25 (6) :728-737.e9. |[2]Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613. |[3]Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK α2β2γ1

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