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LM-189 (free base)

CAT: 0804-HY-171978A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171978A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LM-189 free base, a G protein alpha subunit I (Gαi) -biased agonist, is a Gαi-biased ligand of β2-adrenergic receptor (β2AR) . LM-189 free base stabilizes a distinct conformation in TM6 and increases the dynamics of ICL2. LM-189 free base can be used to develop the Gαi-biased β2AR agonists[1].
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.45
Smiles
OC1=CC=C([C@@H](O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1O
Molecular Formula
C24H35NO4
Molecular Weight
401.54
References & Citations
[1]Casiraghi M, et al. Structure and dynamics determine G protein coupling specificity at a class A GPCR. Sci Adv. 2025 Mar 21;11 (12) :eadq3971.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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