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BI-9740

CAT: 0804-HY-171888Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171888Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC50 of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation[1].
CAS Number
1628596-25-7
UNSPSC
12352005
Target
Cathepsin; Elastase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4[C@]5([H])C[C@](CC5)([H])N4)=O)=CC=C2CC1=O
Molecular Formula
C25H25FN4O2
Molecular Weight
432.49
References & Citations
[1]Liu B, et al. Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats. J Transl Med. 2023 Nov 9;21 (1) :799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin C

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