Scr-IN-1

CAT: 0804-HY-170958Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-170958Size:1 Each

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Description

Scr-IN-1 (Compound 4e) is a Tyrosine kinase inhibitor. Scr-IN-1 inhibits HCT-116 cells and MIA-PaCa-2 cells with IC50s of 0.16 μM and 1.16 μM, respectively. Scr-IN-1 displays selectivity profile on HCT-116 cells and MIA-PaCa-2 cells with SI > 625 and SI > 86, respectively. Scr-IN-1 induces Apoptosis in HCT-116 colon cancer cell and does not cause any change in the rate of necrotic cells. Scr-IN-1 is a novel SRC kinase inhibitor candidate for HCT-116 cells. Scr-IN-1 is potential for cancer research[1].

UNSPSC

12352005

Target

Apoptosis; Src

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1N(C(C2=CC=CC(Cl)=C2)=O)C3=C(C=C(OC(F)(F)F)C=C3)/C1=C\C4=CN(C)C5=C4C=CC=C5

Molecular Formula

C26H16ClF3N2O3

Molecular Weight

496.87

References & Citations

[1]Camcı-Eren M, et al. New 2-indolinone-indole hybrid compounds carrying a benzoyl moiety as tyrosine kinase inhibitors. Bioorg Chem. 2025 Mar;156:108203.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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