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SCR-4026

CAT: 0804-HY-100458Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100458Size:1 Each
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Description
SCR-4026 is a neuroprotective agent with blood-brain barrier penetration ability. SCR-4026 exerts neuroprotective effects by disrupting the interaction between neuronal nNOS and PSD9, with an IC50 of 6.3 μM. SCR-4026 alleviates N-methyl-D-aspartate (NMDA) -induced excitotoxic damage in primary cortical neurons, and also protects neurons in the oxygen-glucose deprivation (OGD) model. SCR-4026 can reduce the cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model. SCR-4026 can be used for the study of stroke[1].
CAS Number
2185855-51-8
UNSPSC
12352005
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C(COC2=C(N)C=C(Cl)C=C2Cl)C=C1)N
Molecular Formula
C14H12Cl2N2O2
Molecular Weight
311.16
References & Citations
[1]Mo SF, et al. Protection of neuronal cells from excitotoxicity by disrupting nNOS-PSD95 interaction with a small molecule SCR-4026. Brain Res. 2016 Oct 1;1648 (Pt A) :250-256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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