SCR7

• UNSPSC Description:

  SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine (HY-107845). SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].

• Target Antigen:

  Apoptosis; CRISPR/Cas9; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SCR7.html

• Purity:

  98.22

• Solubility:

  DMSO : ≥ 45 mg/mL

• Smiles:

  O=C(N1)C(/N=C/C2=CC=CC=C2)=C(NC1=S)/N=C/C3=CC=CC=C3

• Molecular Weight:

  334.39

• References & Citations:

  [1]Srivastava M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151(7):1474-87.|[2]Lin C, et al. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep. 2016 Oct 7;6:34531.|[3]Supriya V Vartak, et al. Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End Joining in a Ligase IV Dependent Manner. FEBS J. 2018 Nov;285(21):3959-3976.BMC Biotechnol. 2021 Jul 27;21(1):45.|EMBO Rep. 2019 Mar;20(3):e46821.|J Genet Genomics. 2021 Mar 30.|J Immunol. 2020 Apr 1;204(7):1904-1918.|J Immunother Cancer. 2022 Jan;10(1):e003809.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Mol Ther Nucleic Acids. 2024 Jul 17;35(3):102274.|Onco Targets Ther. 2018 Aug 17;11:4945-4953.|Sens Actuators B Chem. 19 February 2022, 131598.|Stem Cell Res Ther. 2024 Dec 2;15(1):458.|Viruses. 2023 Nov 14, 15(11), 2256.|Int J Mol Sci. 2022, 23(14), 7518.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1533426-72-0